Tesamorelin Acetate

Description

Tesamorelin Acetate

Chemical Name: Tesamorelin Acetate
Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular Weight: ~5135.9 g/mol
CAS Number: 218949-48-5

Sequence:
H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Gly-Ser-Asn-Gln-Gln-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Lys-Lys-Arg-Arg-Gln-Gln-Gly-Gly-Ser-Asn-Gln-Gln-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-NH₂

Structural Characteristics:
Tesamorelin is a synthetic, stabilized analog of growth hormone-releasing hormone (GHRH 1–44) with a trans-3-hexenoic acid modification at the N-terminal position for enhanced stability. It binds to the GHRH receptor, stimulating growth hormone release in a pulsatile fashion and is utilized in metabolic and endocrine research.

Mechanism of Action (Research Context):
Tesamorelin acts as a GHRH receptor agonist, promoting endogenous growth hormone secretion. Research applications include:

• Studies on visceral adipose tissue reduction
• Lipid metabolism and body composition models
• GH pulsatility and metabolic axis investigations

Synthesis and Quality Control:

• Synthesized via solid-phase peptide synthesis (SPPS)
• Purified to ≥98% by HPLC
• Verified by Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt
• Appearance: White to off-white powder

Solubility:
Tesamorelin Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.

Storage & Handling:

• Store lyophilized powder at –20°C, protected from light and moisture
• After reconstitution, store at 2–8°C for up to 30 days
• For extended storage, aliquot and freeze at –20°C
• Avoid repeated freeze-thaw cycles

Disclaimer:
For research use only. Not intended for human or veterinary use. Not for diagnostic or therapeutic applications.