Retatrutide Acetate

Description

Retatrutide Acetate

Chemical Name: Retatrutide Acetate
Molecular Formula: C₂₁₀H₃₂₅N₅₃O₆₂S · xC₂H₄O₂
Molecular Weight: ~4700.27 g/mol (free base)
CAS Number: 2748043-91-4

Sequence:
H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-C20 fatty diacid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-Ser-Ser-Gly-Ala-Pro-Ser-Pro-Pro-Ser-NH₂
(Lipidated triagonist peptide targeting GLP-1, GIP, and glucagon receptors)

Structural Characteristics:
Retatrutide is a long-acting synthetic triagonist peptide that simultaneously activates the GLP-1, GIP, and glucagon receptors. The sequence includes a C20 fatty acid conjugated via an AEEA linker at Lys20 to enhance albumin binding and extend plasma half-life, making it ideal for chronic metabolic research.

Mechanism of Action (Research Context):
Retatrutide supports multi-receptor incretin and glucagon pathway modulation with potential synergistic effects on:

• Glucose metabolism and insulin sensitivity
• Appetite suppression and energy expenditure
• Hepatic fat reduction and body weight regulation

Synthesis and Quality Control:

• Produced using solid-phase peptide synthesis (SPPS)
• HPLC-purified to ≥98%
• Verified via Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt
• Appearance: White to off-white powder

Solubility:
Retatrutide Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.

Storage & Handling:

• Store lyophilized powder at –20°C, protected from light and moisture
• After reconstitution, refrigerate at 2–8°C for up to 30 days
• For long-term use, aliquot and freeze at –20°C
• Avoid repeated freeze-thaw cycles

Disclaimer:
For research use only. Not intended for human or veterinary use. Not for diagnostic or therapeutic applications.