CJC-1295 with DAC Acetate

Description

CJC-1295 with DAC Acetate

(Drug Affinity Complex)

Chemical Name: CJC-1295 with Drug Affinity Complex (DAC) Acetate
Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: ~3367.88 g/mol
CAS Number: 863288-34-0

Sequence:
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Gly-Ser-Asn-Gln-Gln-Gly-Gly-Gly-Gly
(C-terminal modified with a reactive linker for DAC conjugation)

Structural Characteristics:
CJC-1295 with DAC is a tetrasubstituted analog of growth hormone-releasing hormone (GHRH 1–29) that has been covalently linked to a Drug Affinity Complex (DAC). This modification enables reversible binding to serum albumin, significantly extending its plasma half-life and allowing for sustained stimulation of endogenous growth hormone release.

Mechanism of Action (Research Context):
By binding the GHRH receptor, CJC-1295 with DAC promotes long-lasting elevations in growth hormone (GH) and IGF-1 levels. Research applications include:

• Muscle growth, repair, and hypertrophy models
• Anti-aging and regenerative studies
• Body composition and fat metabolism research
• Endocrine axis and GH pulsatility investigations

Synthesis and Quality Control:

• Manufactured via solid-phase peptide synthesis (SPPS)
• Purified to ≥98% by HPLC
• Verified by Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt
• Appearance: White to off-white powder
• Supplied in: 3mL sterile vial

Solubility & Reconstitution:
Soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.

• Use mildly acidic diluent (pH 5.0–6.5) for optimal stability
• Avoid prolonged air exposure and high pH conditions
• Swirl gently to dissolve

Storage & Handling:

• Store lyophilized powder at –20°C, protected from moisture and light
• After reconstitution, store refrigerated at 2–8°C for up to 30 days
• For extended use, aliquot and freeze at –20°C
• Avoid repeated freeze-thaw cycles

Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.