Description
CJC-1295 with DAC Acetate
(Drug Affinity Complex)
Chemical Name: CJC-1295 with Drug Affinity Complex (DAC) Acetate
Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: ~3367.88 g/mol
CAS Number: 863288-34-0
Sequence:
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Gly-Ser-Asn-Gln-Gln-Gly-Gly-Gly-Gly
(C-terminal modified with a reactive linker for DAC conjugation)
Structural Characteristics:
CJC-1295 with DAC is a tetrasubstituted analog of growth hormone-releasing hormone (GHRH 1–29) that has been covalently linked to a Drug Affinity Complex (DAC). This modification enables reversible binding to serum albumin, significantly extending its plasma half-life and allowing for sustained stimulation of endogenous growth hormone release.
Mechanism of Action (Research Context):
By binding the GHRH receptor, CJC-1295 with DAC promotes long-lasting elevations in growth hormone (GH) and IGF-1 levels. Research applications include:
- Muscle growth, repair, and hypertrophy models
- Anti-aging and regenerative studies
- Body composition and fat metabolism research
- Endocrine axis and GH pulsatility investigations
Synthesis and Quality Control:
- Manufactured via solid-phase peptide synthesis (SPPS)
- Purified to ≥98% by HPLC
- Verified by Mass Spectrometry (MS)
Product Details:
- Form: Lyophilized acetate salt
- Appearance: White to off-white powder
- Supplied in: 3mL sterile vial
Solubility & Reconstitution:
Soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
- Use mildly acidic diluent (pH 5.0–6.5) for optimal stability
- Avoid prolonged air exposure and high pH conditions
- Swirl gently to dissolve
Storage & Handling:
- Store lyophilized powder at –20°C, protected from moisture and light
- After reconstitution, store refrigerated at 2–8°C for up to 30 days
- For extended use, aliquot and freeze at –20°C
- Avoid repeated freeze-thaw cycles
Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.
