Sermorelin Acetate

Description

Sermorelin Acetate

(GRF 1–29)

Chemical Name: Sermorelin Acetate
Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight: ~3357.9 g/mol
CAS Number: 86168-78-7

Sequence:
H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂

Structural Characteristics:
Sermorelin is a 29-amino acid synthetic peptide analog corresponding to the N-terminal fragment of endogenous growth hormone–releasing hormone (GHRH 1–44). It selectively binds to and activates the GHRH receptor on pituitary somatotrophs, stimulating the physiologic release of growth hormone in a pulsatile manner. Due to its shorter half-life compared to modified GHRH analogs, it closely mimics the natural pattern of GH secretion.

Mechanism of Action (Research Context):
Sermorelin is investigated for potential applications in:

• Studying pituitary regulation of growth hormone secretion
• Examining age-related declines in GH production
• Exploring effects on muscle mass, bone density, and metabolism
• Research on recovery, tissue repair, and regenerative pathways through GH–IGF-1 axis modulation

Synthesis and Quality Control:

• Produced via solid-phase peptide synthesis (SPPS)
• Purified to ≥98% by HPLC
• Verified by Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt
• Appearance: White to off-white powder
• Supplied in: 3mL sterile vial

Solubility & Reconstitution:
Soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.

• Swirl gently to dissolve; avoid vigorous shaking
• Protect from oxidation and high pH to maintain peptide stability

Storage & Handling:

• Store lyophilized powder at –20°C, protected from light and moisture
• After reconstitution, store at 2–8°C for up to 30 days
• For extended storage, aliquot and freeze at –20°C
• Avoid repeated freeze-thaw cycles

Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.