Melanotan 1 Acetate

Description

Melanotan 1 Acetate (MT-1)

Chemical Name: Afamelanotide (Melanotan I) Acetate
Molecular Formula: C₇₈H₁₁₁N₂₁O₁₉
Molecular Weight: ~1646.88 g/mol
CAS Number: 75921-69-6

Sequence:
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂
(Nle = Norleucine)

Structural Characteristics:
Melanotan 1 (Afamelanotide) is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH). It is designed to bind with high affinity to the melanocortin 1 receptor (MC1R), promoting melanogenesis while minimizing systemic hormonal effects. MT-1 is used widely in pigmentation research and photoprotection models.

Mechanism of Action (Research Context):
By acting as an MC1R agonist, MT-1 increases eumelanin production in melanocytes. Its research applications include:

• Studies on UV-induced DNA protection and pigmentation
• Investigations into melanoma and melanocyte biology
• Photoprotective and oxidative stress response research

Synthesis and Quality Control:

• Synthesized via solid-phase peptide synthesis (SPPS)
• Purified to ≥98% by HPLC
• Identity confirmed by Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt
• Appearance: White to off-white powder

Solubility:
Melanotan 1 Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.

Storage & Handling:

• Store lyophilized powder at –20°C, away from light and moisture.
• After reconstitution, refrigerate at 2–8°C and use within 30 days.
• For long-term storage, aliquot and freeze at –20°C.
• Avoid repeated freeze-thaw cycles.

Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.