Ipamorelin Acetate

Description

Ipamorelin Acetate

Chemical Name: Ipamorelin Acetate
Molecular Formula: C₃₈H₄₉N₉O₅
Molecular Weight: ~711.86 g/mol
CAS Number: 170851-70-4

Sequence:
Aib-His-D-2-Nal-D-Phe-Lys-NH₂
(Aib = α-aminoisobutyric acid, 2-Nal = 2-naphthylalanine)

Structural Characteristics:
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) that selectively activates the ghrelin receptor (GHS-R1a) to stimulate endogenous growth hormone (GH) release. It is highly selective, producing minimal to no stimulation of ACTH, cortisol, or prolactin compared to other GHRP-class peptides.

Mechanism of Action (Research Context):
Ipamorelin is studied for its ability to promote pulsatile GH secretion, with applications in:

• Muscle development, recovery, and repair
• Lean body mass preservation
• Fat metabolism and energy regulation
• Synergistic GH stimulation when combined with GHRH analogs (e.g., Mod-GRF 1–29)

Synthesis and Quality Control:

• Produced via solid-phase peptide synthesis (SPPS)
• HPLC purified to ≥98%
• Verified by Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt
• Appearance: White to off-white powder
• Supplied in: 3mL sterile vial

Solubility & Reconstitution:
Soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.

• Use mildly acidic diluent (pH 5.0–6.5) for optimal stability
• Swirl gently to dissolve; avoid vigorous shaking

Storage & Handling:

• Store lyophilized powder at –20°C, protected from moisture and light
• After reconstitution, refrigerate at 2–8°C for up to 30 days
• For long-term use, aliquot and freeze at –20°C
• Avoid repeated freeze-thaw cycles

Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.