Description
GLP-3
Chemical Name: GLP-3
Molecular Formula: C₂₁₀H₃₂₅N₅₃O₆₂S · xC₂H₄O₂
Molecular Weight: ~4700.27 g/mol (free base)
CAS Number: 2748043-91-4
Sequence:
H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-C20 fatty diacid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-Ser-Ser-Gly-Ala-Pro-Ser-Pro-Pro-Ser-NH₂
(Lipidated triagonist peptide targeting GLP-1, GIP, and glucagon receptors)
Structural Characteristics:
GLP-3 is a long-acting synthetic triagonist peptide that simultaneously activates the GLP-1, GIP, and glucagon receptors. The sequence includes a C20 fatty acid conjugated via an AEEA linker at Lys20 to enhance albumin binding and extend plasma half-life, making it ideal for chronic metabolic research.
Mechanism of Action (Research Context):
GLP-3 supports multi-receptor incretin and glucagon pathway modulation with potential synergistic effects on:
- Glucose metabolism and insulin sensitivity
- Appetite suppression and energy expenditure
- Hepatic fat reduction and body weight regulation
Synthesis and Quality Control:
- Produced using solid-phase peptide synthesis (SPPS)
- HPLC-purified to ≥98%
- Verified via Mass Spectrometry (MS)
Product Details:
- Form: Lyophilized acetate salt
- Appearance: White to off-white powder
Solubility:
GLP-3 is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
Storage & Handling:
- Store lyophilized powder at –20°C, protected from light and moisture
- After reconstitution, refrigerate at 2–8°C for up to 30 days
- For long-term use, aliquot and freeze at –20°C
- Avoid repeated freeze-thaw cycles
Disclaimer:
For research use only. Not intended for human or veterinary use. Not for diagnostic or therapeutic applications.
