GLP-1 – 10mg

Description

GLP-1

Chemical Name: GLP-1
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: ~4113.6 g/mol
CAS Number: 910463-68-2

Sequence:
H-Aib-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(N-(γ-Glu-2xOEG)-OEG-C18 diacid)-Glu-Glu-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
(Aib = α-aminoisobutyric acid, OEG = oxyethylene glycol)

Structural Characteristics:
GLP-1 is a 31-amino acid synthetic GLP-1 receptor agonist analog with substitutions and a C18 fatty diacid side chain attached via a spacer to Lys26. This modification enhances albumin binding, slows enzymatic degradation, and prolongs its plasma half-life for extended receptor activation.

Mechanism of Action (Research Context):
GLP-1 is studied for its selective activation of the GLP-1 receptor, with potential applications in:

• Glycemic regulation and β-cell function research
• Appetite suppression and satiety signaling studies
• Weight management and adiposity reduction models
• Cardiometabolic health and lipid profile investigations

Synthesis and Quality Control:

• Produced via solid-phase peptide synthesis (SPPS) with site-specific lipidation
• Purified to ≥98% by HPLC
• Identity confirmed by Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt
• Appearance: White to off-white powder
• Supplied in: 3mL sterile vial

Solubility & Reconstitution:
Soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.

• Swirl gently to dissolve; avoid vigorous shaking
• Protect from oxidation and high pH to maintain structural integrity

Storage & Handling:

• Store lyophilized powder at –20°C, away from light and moisture
• After reconstitution, refrigerate at 2–8°C for up to 30 days
• For extended storage, aliquot and freeze at –20°C
• Avoid repeated freeze-thaw cycles

Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.