GHK-Cu Acetate

Description

GHK-Cu Acetate

(Copper Tripeptide-1)

Chemical Name: Glycyl-L-histidyl-L-lysine:copper(II) Acetate
Molecular Formula: C₁₄H₂₄CuN₆O₄
Molecular Weight: ~340.9 g/mol
CAS Number: 49557-75-7

Sequence:
Gly-His-Lys (complexed with divalent copper)

Structural Characteristics:
GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. In its acetate form, the peptide is complexed with a copper(II) ion, which is crucial for its biological activity in tissue remodeling, wound healing, and regenerative processes.

Mechanism of Action (Research Context):
GHK-Cu is studied for its ability to promote tissue repair and regeneration by:

• Stimulating collagen, elastin, and glycosaminoglycan synthesis
• Enhancing angiogenesis and wound healing
• Supporting antioxidant and anti-inflammatory pathways
• Regulating gene expression related to cell growth and repair
• Protecting dermal fibroblasts and keratinocytes from oxidative damage

Synthesis and Quality Control:

• Produced via solid-phase peptide synthesis (SPPS) and copper chelation
• HPLC purified to ≥98%
• Verified by Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt (copper-complexed)
• Appearance: Blue to blue-green powder
• Supplied in: 3mL sterile vial

Solubility & Reconstitution:
Soluble in sterile water or aqueous buffers at pH 5–7.

• Avoid strong chelating agents (e.g., EDTA) that can remove copper from the complex
• Swirl gently to dissolve; do not shake vigorously

Storage & Handling:

• Store lyophilized powder at –20°C, away from light and moisture
• After reconstitution, store at 2–8°C for up to 14 days
• For long-term storage, aliquot and freeze at –20°C
• Avoid repeated freeze-thaw cycles

Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.