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Mod-GRF (1–29) (CJC-1295 w/o DAC) Acetate
$45.07
Mod-GRF (1-29) Acetate—also known as CJC-1295 without DAC—is a synthetic 29-amino acid, tetrasubstituted analog of growth hormone-releasing hormone (GHRH), developed for research into pulsatile GH secretion, pituitary signaling, and IGF-1 axis modulation. Engineered with substitutions at positions 2, 8, 15, and 27, Mod-GRF (1-29) offers enhanced proteolytic stability while maintaining a short-acting profile that mimics physiologic GH pulse dynamics, supporting studies on anabolic pathways, body composition, and metabolic regulation.
Supplied as a lyophilized acetate salt, Mod-GRF (1-29) is optimized for sterility, stability, and extended shelf life. Provided in a 3mL vial, this GHRH analog is ideal for research requiring transient GH stimulation without prolonged receptor activation.
Solubility: Mod-GRF (1-29) is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
For laboratory research use only. Not for human or veterinary applications.
Description
CJC-1295 without DAC
(Also known as Mod GRF 1-29)
Chemical Name: CJC-1295 without Drug Affinity Complex (DAC)
Molecular Formula: C₁₅₂H₂₄₄N₄₆O₄₂
Molecular Weight: ~3367.2 g/mol
CAS Number: 863288-34-0
Sequence:
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Gly-Ser-Asn-Gln-Gln-Gly-Gly-Gly-Gly
Structural Characteristics:
CJC-1295 without DAC, also referred to as Mod GRF 1-29, is a stabilized analog of growth hormone-releasing hormone (GHRH 1–29). It includes four amino acid substitutions for enhanced metabolic stability and half-life, without the need for Drug Affinity Complex (DAC) conjugation.
Mechanism of Action (Research Context):
CJC-1295 without DAC stimulates the GHRH receptor, promoting natural, pulsatile release of endogenous growth hormone. GH influences a variety of physiological processes, and this peptide is studied for its role in:
- Promoting muscle development, hypertrophy, and repair
- Enhancing protein synthesis and nitrogen retention
- Supporting lipolysis and lean body composition
- Regulating IGF-1 production and tissue regeneration
- Modulating growth hormone pulsatility without receptor desensitization
Synthesis and Quality Control:
- Manufactured via solid-phase peptide synthesis (SPPS)
- HPLC purified to ≥98%
- Verified by Mass Spectrometry (MS)
Product Details:
- Form: Lyophilized acetate salt
- Appearance: White to off-white powder
- Supplied in: 3mL sterile vial
Solubility & Reconstitution:
Soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
- Swirl gently to dissolve
- Avoid high pH and exposure to oxygen
Storage & Handling:
- Store lyophilized powder at –20°C, protected from light and moisture
- After reconstitution, refrigerate at 2–8°C for up to 30 days
- For extended use, aliquot and freeze at –20°C
- Avoid repeated freeze-thaw cycles
Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.
Additional information
| Weight | .06 lbs |
|---|---|
| Dimensions | .5 × .5 × 1 in |
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