AOD 9604 Acetate

Description

AOD-9604 Acetate

Chemical Name: AOD-9604 Acetate
Molecular Formula: C₇₈H₁₂₅N₂₃O₂₃S₂
Molecular Weight: ~1817.1 g/mol
CAS Number: 221231-10-3

Sequence:
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Gly-Phe-Gly

Structural Characteristics:
AOD-9604 is a synthetic analog of the C-terminal fragment (176–191) of human growth hormone (hGH), with the addition of a tyrosine residue at the N-terminus for enhanced stability. It retains the fat metabolism–modulating properties of hGH without significantly affecting blood glucose or growth-promoting activity.

Mechanism of Action (Research Context):
AOD-9604 has been investigated for its ability to regulate lipid metabolism by:

• Stimulating lipolysis (fat breakdown)
• Inhibiting lipogenesis (fat formation)
• Supporting studies in obesity, metabolic disorders, and weight regulation

It is often compared to hGH Fragment 176–191 but is chemically distinct, featuring a norleucine substitution for improved stability.

Synthesis and Quality Control:

• Manufactured via solid-phase peptide synthesis (SPPS)
• Purified to ≥98% by HPLC
• Verified by Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt
• Appearance: White to off-white powder
• Supplied in: 3mL sterile vial

Solubility & Reconstitution:
AOD-9604 is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–6.

• This peptide is pH-sensitive and may gel in higher pH solutions or with prolonged exposure to oxygen
• For optimal reconstitution, use sterile water with pH ~5.5 and minimize air exposure

Storage & Handling:

• Store lyophilized powder at –20°C, away from light and moisture
• After reconstitution, refrigerate at 2–8°C for up to 30 days
• For long-term use, aliquot and freeze at –20°C
• Avoid repeated freeze-thaw cycles

Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.