Description
Adipotide Acetate (FTPP)
Chemical Name: Adipotide (FTPP) Acetate
Molecular Formula: C₆₀H₉₁N₁₇O₁₆S₂
Molecular Weight: ~1395.6 g/mol
CAS Number: 1009865-66-2
Sequence:
CKGGRAKDC-GG-D(KLAKLAK)₂
(KLAKLAK = pro-apoptotic domain; CKGGRAKDC = vascular targeting motif)
Structural Characteristics:
Adipotide (FTPP) is a chimeric peptidomimetic consisting of two functional regions:
- A homing domain that targets adipose tissue vasculature via binding to prohibitin on endothelial cells
- A pro-apoptotic domain that disrupts mitochondrial membranes in targeted cells, leading to selective apoptosis of white adipose vasculature
Mechanism of Action (Research Context):
Adipotide has been investigated for its unique ability to reduce white adipose tissue mass via vascular-targeted apoptosis. Applications include:
- Obesity and metabolic syndrome research models
- Investigations into targeted fat loss and angiogenesis
- Studies on energy balance, lipid redistribution, and adipocyte biology
Synthesis and Quality Control:
- Synthesized via solid-phase peptide synthesis (SPPS)
- HPLC purified to ≥98%
- Identity verified by Mass Spectrometry (MS)
Product Details:
- Form: Lyophilized acetate salt
- Appearance: White to off-white powder
- Supplied in: 3mL sterile vial
Solubility & Reconstitution:
Adipotide Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers between pH 5 and 7.
For optimal results:
- Use freshly opened bacteriostatic water or sterile saline
- Avoid high pH or oxidizing conditions which may affect solubility or stability
- Swirl gently to dissolve; avoid foaming
Storage & Handling:
- Store lyophilized powder at –20°C, protected from light and humidity
- After reconstitution, store at 2–8°C for up to 30 days
- For extended storage, aliquot and freeze at –20°C
- Avoid repeated freeze-thaw cycles and prolonged exposure to oxygen
Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.
