Adipotide (FTPP) Acetate
$79.90
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Adipotide (FTPP) is a synthetic peptidomimetic composed of a homing peptide (CKGGRAKDC) linked to a pro-apoptotic domain (KLAKLAK₂), engineered for targeted research into adipose tissue vasculature and selective apoptosis of white adipocytes. By binding to prohibitin complexes on the surface of adipose-associated endothelial cells, Adipotide induces mitochondrial disruption and cell death, supporting studies into fat mass reduction, metabolic disorders, and vascular targeting strategies.
Supplied as a lyophilized peptide, Adipotide is optimized for sterility, stability, and extended shelf life.
Provided in a 3mL vial, this vascular-targeting compound is suitable for research focused on obesity models, angiogenesis inhibition, and apoptotic pathway modulation in adipose tissues.
Solubility: Adipotide is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
For laboratory research use only. Not for human or veterinary applications.
Description
Adipotide Acetate (FTPP)
Chemical Name: Adipotide (FTPP) Acetate
Molecular Formula: C₆₀H₉₁N₁₇O₁₆S₂
Molecular Weight: ~1395.6 g/mol
CAS Number: 1009865-66-2
Sequence:
CKGGRAKDC-GG-D(KLAKLAK)₂
(KLAKLAK = pro-apoptotic domain; CKGGRAKDC = vascular targeting motif)
Structural Characteristics:
Adipotide (FTPP) is a chimeric peptidomimetic consisting of two functional regions:
- A homing domain that targets adipose tissue vasculature via binding to prohibitin on endothelial cells
- A pro-apoptotic domain that disrupts mitochondrial membranes in targeted cells, leading to selective apoptosis of white adipose vasculature
Mechanism of Action (Research Context):
Adipotide has been investigated for its unique ability to reduce white adipose tissue mass via vascular-targeted apoptosis. Applications include:
- Obesity and metabolic syndrome research models
- Investigations into targeted fat loss and angiogenesis
- Studies on energy balance, lipid redistribution, and adipocyte biology
Synthesis and Quality Control:
- Synthesized via solid-phase peptide synthesis (SPPS)
- HPLC purified to ≥98%
- Identity verified by Mass Spectrometry (MS)
Product Details:
- Form: Lyophilized acetate salt
- Appearance: White to off-white powder
- Supplied in: 3mL sterile vial
Solubility & Reconstitution:
Adipotide Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers between pH 5 and 7.
For optimal results:
- Use freshly opened bacteriostatic water or sterile saline
- Avoid high pH or oxidizing conditions which may affect solubility or stability
- Swirl gently to dissolve; avoid foaming
Storage & Handling:
- Store lyophilized powder at –20°C, protected from light and humidity
- After reconstitution, store at 2–8°C for up to 30 days
- For extended storage, aliquot and freeze at –20°C
- Avoid repeated freeze-thaw cycles and prolonged exposure to oxygen
Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.
Additional information
| Weight | .06 lbs |
|---|---|
| Dimensions | .5 × .5 × 1 in |
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