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Semaglutide Acetate – 5mg
$45.72
Semaglutide Acetate is a synthetic 31-amino acid GLP-1 receptor agonist engineered for research into glucose regulation, appetite suppression, and metabolic signaling. This peptide is a modified analog of native glucagon-like peptide-1, incorporating substitutions for DPP-4 resistance and a C18 fatty diacid side chain for albumin binding, extending its half-life and supporting long-acting incretin-based studies. Semaglutide promotes insulin secretion, reduces glucagon release, and delays gastric emptying, making it a model compound for investigations into obesity, type 2 diabetes, and energy balance.
Supplied as a lyophilized acetate salt, Semaglutide Acetate is optimized for sterility, stability, and extended shelf life. Provided in a 3 mL vial, this lipidated GLP-1 analog is ideal for studies involving glycemic control, satiety mechanisms, and long-acting peptide pharmacology.
Solubility: Semaglutide Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
For laboratory research use only. Not for human or veterinary applications.
Description
Semaglutide Acetate
Chemical Name: Semaglutide Acetate
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: ~4113.6 g/mol
CAS Number: 910463-68-2
Sequence:
H-Aib-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(N-(γ-Glu-2xOEG)-OEG-C18 diacid)-Glu-Glu-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
(Aib = α-aminoisobutyric acid, OEG = oxyethylene glycol)
Structural Characteristics:
Semaglutide is a 31-amino acid synthetic GLP-1 receptor agonist analog with substitutions and a C18 fatty diacid side chain attached via a spacer to Lys26. This modification enhances albumin binding, slows enzymatic degradation, and prolongs its plasma half-life for extended receptor activation.
Mechanism of Action (Research Context):
Semaglutide is studied for its selective activation of the GLP-1 receptor, with potential applications in:
- Glycemic regulation and β-cell function research
- Appetite suppression and satiety signaling studies
- Weight management and adiposity reduction models
- Cardiometabolic health and lipid profile investigations
Synthesis and Quality Control:
- Produced via solid-phase peptide synthesis (SPPS) with site-specific lipidation
- Purified to ≥98% by HPLC
- Identity confirmed by Mass Spectrometry (MS)
Product Details:
- Form: Lyophilized acetate salt
- Appearance: White to off-white powder
- Supplied in: 3mL sterile vial
Solubility & Reconstitution:
Soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
- Swirl gently to dissolve; avoid vigorous shaking
- Protect from oxidation and high pH to maintain structural integrity
Storage & Handling:
- Store lyophilized powder at –20°C, away from light and moisture
- After reconstitution, refrigerate at 2–8°C for up to 30 days
- For extended storage, aliquot and freeze at –20°C
- Avoid repeated freeze-thaw cycles
Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.
Additional information
| Weight | .06 lbs |
|---|---|
| Dimensions | .5 × .5 × 1 in |
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