PT-141 Acetate

Description

PT-141 Acetate (Bremelanotide)

Chemical Name: Bremelanotide Acetate
Molecular Formula: C₅₀H₆₈N₁₄O₁₀
Molecular Weight: ~1025.2 g/mol
CAS Number: 189691-06-3

Sequence:
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH
(Nle = Norleucine; c = cyclic lactam bridge between Asp and Lys)

Structural Characteristics:
PT-141 (Bremelanotide) is a cyclic heptapeptide and melanocortin receptor agonist. Unlike traditional PDE5 inhibitors, PT-141 exerts its effects via central melanocortin pathways (MC3R and MC4R), making it a unique tool for sexual function and neuroendocrine signaling research.

Mechanism of Action (Research Context):
PT-141 is studied for its impact on sexual arousal and libido through CNS-mediated pathways. It does not act directly on the vascular system. Research applications include:

• Sexual function and behavior studies
• Investigations into central melanocortin receptor signaling
• Appetite regulation and energy homeostasis models

Synthesis and Quality Control:

• Synthesized via solid-phase peptide synthesis (SPPS)
• Purified to ≥98% by HPLC
• Identity confirmed by Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt
• Appearance: White to off-white powder

Solubility:
PT-141 Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.

Storage & Handling:

• Store lyophilized powder at –20°C, protected from light and moisture
• After reconstitution, refrigerate at 2–8°C for up to 30 days
• For extended use, aliquot and freeze at –20°C
• Avoid repeated freeze-thaw cycles

Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.