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MOTS-c Acetate
$66.41
MOTS-c Acetate is a 16-amino acid mitochondrial-derived peptide (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg) encoded by the mitochondrial 12S rRNA gene, developed for research into metabolic regulation, insulin sensitivity, and mitochondrial signaling pathways. MOTS-c has been shown in preclinical studies to activate AMPK, promote fatty acid oxidation, and enhance cellular stress resilience, supporting investigations into aging, exercise adaptation, and metabolic homeostasis.
Supplied as a lyophilized acetate salt, MOTS-c Acetate is optimized for sterility, stability, and extended shelf life. Provided in a 3 mL vial, this peptide is ideal for studies on mitochondrial–nuclear communication, glucose metabolism, and stress-response pathways.
Solubility: MOTS-c Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
For laboratory research use only. Not for human or veterinary applications.
Description
MOTS-c Acetate
Chemical Name: Mitochondrial Open Reading Frame of the 12S rRNA Type-c (MOTS-c) Acetate
Molecular Formula: C₁₀₂H₁₅₇N₂₇O₃₂
Molecular Weight: ~2176.4 g/mol
CAS Number: 1610353-26-2
Sequence:
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Structural Characteristics:
MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. It plays a regulatory role in metabolic homeostasis and cellular stress adaptation, with the ability to translocate to the nucleus under stress conditions to modulate gene expression.
Mechanism of Action (Research Context):
MOTS-c is studied for its effects on metabolic and stress-response pathways, including:
- Activation of AMPK (AMP-activated protein kinase)
- Regulation of glucose utilization and lipid metabolism
- Enhancement of exercise capacity and mitochondrial function
- Modulation of insulin sensitivity and inflammatory signaling
Synthesis and Quality Control:
- Manufactured using solid-phase peptide synthesis (SPPS)
- HPLC purified to ≥98%
- Identity verified by Mass Spectrometry (MS)
Product Details:
- Form: Lyophilized acetate salt
- Appearance: White to off-white powder
- Supplied in: 3mL sterile vial
Solubility & Reconstitution:
MOTS-c Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
- Swirl gently to dissolve; avoid vigorous shaking
- Protect from high pH or oxidative conditions to preserve stability
Storage & Handling:
- Store lyophilized powder at –20°C, away from moisture and light
- After reconstitution, refrigerate at 2–8°C for up to 30 days
- For extended use, aliquot and freeze at –20°C
- Avoid repeated freeze-thaw cycles
Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.
Additional information
| Weight | .06 lbs |
|---|---|
| Dimensions | .5 × .5 × 1 in |
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