Description
GLP-2 TZ
Chemical Name: GLP-2 TZ
Molecular Formula: C₂₂₅H₃₄₂N₄₆O₆₈
Molecular Weight: ~4813.5 g/mol
CAS Number: 2023788-19-2
Sequence:
H-His-Ala-Ala-Pro-Ser-Pro-Gly-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Gly-Glu-Gly-Val-Gly-Gly-Gly-Gly-Cys-Lys(AEEA-C20 diacid)-Ala-Ala-Ala-Glu-Gly-Glu-Leu-Gln-Gly-Ala-Leu-Glu-Gly-Gly-Gly-Thr-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-Arg-Gly-Cys-His-Ala-Ile-Ala-Asp-Leu-Glu-Ser-Leu-Gln-Gly-Glu-Leu-Ser-Ser-Leu-Gln-Ser-Glu-Leu-Ser-Glu-Gly-Ala-Gln-Ala-Lys-NH₂
Structural Characteristics:
GLP-2 TZ is a 39-amino acid synthetic peptide analog that functions as a dual agonist at the glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor. It is lipidated at Lys20 via a hydrophilic AEEA linker to a C20 fatty diacid, enhancing albumin binding and extending plasma half-life.
Mechanism of Action (Research Context):
Tirzepatide has been studied for its ability to activate both GIP and GLP-1 receptors, with research applications in:
- Glycemic regulation and insulin sensitivity models
- Appetite and satiety signaling studies
- Body weight and adiposity reduction research
- Lipid metabolism and metabolic syndrome investigations
Synthesis and Quality Control:
- Produced via solid-phase peptide synthesis (SPPS) with site-specific lipidation
- HPLC purified to ≥98%
- Identity confirmed by Mass Spectrometry (MS)
Product Details:
- Form: Lyophilized acetate salt
- Appearance: White to off-white powder
- Supplied in: 3mL sterile vial
Solubility & Reconstitution:
Soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
- Swirl gently to dissolve; avoid vigorous shaking
- Protect from high pH and oxidative conditions
Storage & Handling:
- Store lyophilized powder at –20°C, away from light and moisture
- After reconstitution, refrigerate at 2–8°C for up to 30 days
- For extended storage, aliquot and freeze at –20°C
- Avoid repeated freeze-thaw cycles
Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.
