Description
GHRP-2 Acetate
Chemical Name: Growth Hormone Releasing Peptide-2 (GHRP-2) Acetate
Molecular Formula: C₄₅H₅₅N₉O₆
Molecular Weight: ~817.97 g/mol
CAS Number: 158861-67-7
Sequence:
D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂
(2-Nal = 2-naphthylalanine)
Structural Characteristics:
GHRP-2 is a synthetic hexapeptide belonging to the growth hormone secretagogue (GHS) family. It functions as a potent ghrelin receptor (GHS-R1a) agonist and stimulates pulsatile release of endogenous growth hormone without significantly affecting ACTH or cortisol levels.
Mechanism of Action (Research Context):
GHRP-2 binds to the ghrelin receptor in the hypothalamus and pituitary, enhancing growth hormone release and amplifying pituitary response to GHRH. Applications include:
- Investigations into GH signaling and endocrine regulation
- Research on body composition, appetite, and energy homeostasis
- Anti-aging and muscle-wasting model studies
Synthesis and Quality Control:
- Synthesized via solid-phase peptide synthesis (SPPS)
- Purity ≥98% by HPLC
- Identity verified by Mass Spectrometry (MS)
Product Details:
- Form: Lyophilized acetate salt
- Appearance: White to off-white powder
Solubility:
GHRP-2 Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.
Storage & Handling:
- Store lyophilized powder at –20°C, protected from light and moisture.
- After reconstitution, store at 2–8°C for up to 30 days.
- For extended storage, aliquot and freeze at –20°C.
- Avoid repeated freeze-thaw cycles.
Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.
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