Melanotan 2 Acetate

Description

Melanotan 2 Acetate (MT-2)

Chemical Name: Melanotan II Acetate
Molecular Formula: C₅₀H₆₉N₁₅O₉
Molecular Weight: ~1024.18 g/mol
CAS Number: 121062-08-6

Sequence:
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
(Nle = Norleucine; c = cyclic lactam bridge between Asp and Lys)

Structural Characteristics:
Melanotan 2 is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH), designed to bind with high affinity to melanocortin receptors (MC1R, MC3R, MC4R, MC5R). The cyclic structure enhances stability and receptor selectivity compared to linear analogs.

Mechanism of Action (Research Context):
MT-2 is studied for its ability to stimulate melanogenesis via MC1R activation, increasing eumelanin production in skin cells. It has also been investigated for central melanocortin receptor effects related to:

• Pigmentation and photoprotection studies
• Appetite regulation and energy expenditure models
• Sexual function research through MC3R and MC4R pathways

Synthesis and Quality Control:

• Manufactured via solid-phase peptide synthesis (SPPS)
• Purified to ≥98% by HPLC
• Identity confirmed by Mass Spectrometry (MS)

Product Details:

• Form: Lyophilized acetate salt
• Appearance: White to off-white powder
• Supplied in: 3mL sterile vial

Solubility & Reconstitution:
Melanotan 2 Acetate is soluble in sterile water, dilute acetic acid, or aqueous buffers at pH 5–7.

• Swirl gently to dissolve; avoid vigorous agitation
• Protect reconstituted solution from prolonged light exposure to maintain stability

Storage & Handling:

• Store lyophilized powder at –20°C, protected from light and moisture
• After reconstitution, refrigerate at 2–8°C for up to 30 days
• For extended storage, aliquot and freeze at –20°C
• Avoid repeated freeze-thaw cycles

Disclaimer:
For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic applications.